William married Mary Elizabeth Prather on 24 Jan 1856 in , Jefferson , Iowa, United States. Mary (daughter of James Russell Prather and Louvica Caroline Veatch) was born on 21 Nov 1831 in , Clark, Indiana, United States; died on 16 Oct 1909 in , Skagit, Washington, United States. [Group Sheet] [Family Chart]

1. Francis Russell Asbury Hamilton was born on 30 Sep 1857 in Ashland, Wapello, Iowa, United States; died on 16 Aug 1913 in Sedro Woolley, Skagit County, Washington, United States; was buried on 16 Aug 1913 in Union Cemetery, Sedro-Woolley, Skagit, Washington, United States.
2. Edwin Perry L. Hamilton was born on 15 Mar 1859 in Simpson, Clay, Iowa, United States; died on 17 Dec 1922 in Pleasant Grove, Sutter County, California, United States.
3. Emma Agusta Hamilton was born on 18 Feb 1861 in , , Iowa, United States; died on 8 Jan 1907 in Eugene, Lane County, Oregon, United States.
4. Infant Hamilton was born in Oct 1862 in Fort Churchill, Lyon County, Nevada, United States; died in Oct 1862 in Fort Churchill, Lyon County, Nevada, United States.
5. Charles Grant Hamilton was born on 23 Sep 1865 in Stoney Point, Sonoma County, California, United States; died on 30 Jun 1934 in Reno, Washoe County, Nevada, United States.

William married Nancy Mann Billingsley on 18 Apr 1833 in , Butler, Ohio, United States. Nancy was born on 26 May 1814 in , , Indiana, United States; died on 31 May 1855 in Ashland, Wapello, Iowa, United States. [Group Sheet] [Family Chart]

1. George Washington Hamilton was born on 24 Apr 1834 in Middleton, Butler County, Ohio, United States; died on 21 May 1915 in Piedmont, Alameda County, California, United States.
2. John H. Hamilton was born on 28 Feb 1837 in Middleton, Butler County, Ohio, United States; died on 21 Aug 1909 in Elmhurst, Alameda, California, United States.
3. William Franklin Hamilton was born on 16 Feb 1840 in Shelbyville, Shelby County, Indiana, United States; died on 14 Apr 1918 in Stromsburg, Polk County, Nebraska, United States.
4. James Henry Hamilton was born on 6 Apr 1842 in Shelbyville, Shelby County, Indiana, United States; died on 20 May 1888 in York, York County, Nebraska, United States.
5. Amanda Elizabeth Hamilton was born on 12 Jun 1844 in Shelbyville, Shelby County, Indiana, United States; died on 13 May 1923 in Seattle, King County, Washington, United States; was cremated on 16 May 1923 in Seattle, King County, Washington, United States.
6. Mary Frances Hamilton was born on 22 Aug 1851 in Carthage, Hancock County, Illinios, United States; died on 15 May 1930 in Malott, Okanogan County, Washington, United States; was buried on 17 May 1930 in Malott Community Cemetery.