Samuel married Anna Nancy Prather in 1804. Anna (daughter of John Garrett Prather and Amelia Phillips) was born on 27 Apr 1787 in , Frederick, Maryland, United States; died on 26 Jul 1870 in , Clermont, Ohio, United States. [Group Sheet] [Family Chart]

1. John Slye was born on 12 Nov 1805; and died.
2. Amelia Slye was born on 9 Feb 1807; and died.
3. William Slye was born on 30 Aug 1808; and died.
4. James Slye was born on 11 Aug 1810; and died.
5. Nancy Ann Slye was born on 20 Oct 1814; and died.
6. Nellie Ann Slye was born on 24 Dec 1816; and died.
7. Cicero Slye was born on 4 Apr 1820; and died.
8. Eliza Slye was born on 11 Sep 1822; and died.
9. Elizabeth Slye was born on 20 Aug 1824; and died.
10. Sarah Slye was born on 4 Oct 1827; and died.